NIIT University Industry Academic Partnerships
 |
| NIIT University Industry Academic Partnerships |
NIIT University Industry-Academic Partnerships:-
NU has innovated unique forms of partnering with the industry leading to value creation for the industry and ensuring faculty & students understand needs of the industry and apply their academic knowledge to develop applications of societal benefit.
Industry Practice is a flagship course of 20 credits in the B Tech Programme of NIIT University. Every student of NIIT University has an opportunity to transfer learning from classroom to the workplace in industry in the final six-month semester of B Tech Programme. During Industry Practice, a student works on the real time project of an organization under direct mentoring by industry professional. This 6-month period makes the transition from student in a University to an employed professional in industry seamless or smooth for a student. A similar course termed Internship is offered at the Masters level.
Placements at NU is handled by its Centre for Industry Collaboration (CIC). The Centre for Industry Collaboration is headed by a full-time placement specialist. It is also responsible to assist students to find the right fit for Industry Practice. It nurtures students to enrich their education, career and lives and make lifelong contributions to society. To facilitate career development, our placement specialist, works in coordination with senior faculty coordinators from within the University, and student representatives from each domain of Engineering and Management studies and a large number of industries.
Work Integrated Programmes are unique academic programmes offered to working professionals that enable them to pursue academic degrees while continuing to work in their respective organizations. Each course in the programme draws its hands-on and lab work component from the work undertaken in the organization. By doing so, it enriches both the world of work and the world of study.
Industry Sponsored Programmes are designed in close consultation with the industry to address its immediate and future needs. The students of the programmes may have already been working in the respective industry or may be absorbed in the industry after successful completion of the programme. Industry Sponsored Programmes combine the best of both the university and industry by bringing in academic rigour to the knowledge and skill sets that the industry requires its personnel to acquire.
Centres of Innovation are another way to bring the industry into the university. These centres are equipped with the latest technologies required to meet future needs of the industry and students are encouraged to explore and come up with ideas of entrepreneurial value.
Industry Practice
Industry Practice (IP) is a flagship course of 20 credits in the B. Tech Programme of NIIT University.
It is an educational instrument seeking to link industry experience with university instruction. Every student of NIIT University has an opportunity to transfer learning from classroom to the workplace in industry in the 7th or 8th semester of the final year of B Tech Programme. During Industry Practice, a student works on a live project of the organization under direct mentorship by industry professional. This period makes the transition from student in a university to an employed professional in industry seamless for the students. A similar course termed Internship is offered at the Masters level.
Industry Practice (IP) is a flagship course of 20 credits in the B. Tech Programme of NIIT University.
It is an educational instrument seeking to link industry experience with university instruction. Every student of NIIT University has an opportunity to transfer learning from classroom to the workplace in industry in the 7th or 8th semester of the final year of B Tech Programme. During Industry Practice, a student works on a live project of the organization under direct mentorship by industry professional. This period makes the transition from student in a university to an employed professional in industry seamless for the students. A similar course termed Internship is offered at the Masters level.
The objectives of IP are to (i) meet the rapidly changing needs and challenges of a professional workplace, (ii) enable students to acquire learning by applying the knowledge and skills they possess, in unfamiliar, open-ended real life situations, and (iii) bear an economic relevance to society. These objectives are achieved by bringing the reality of the world of work into the process of education. IP creates the required setting for experiential and cooperative learning and education, by providing students with an opportunity to work on relevant assignments, under the guidance of professional experts and under the supervision of faculty. The Centre for Industry Collaboration (CIC) facilitates and promotes partnership and intellectual exchange between academia and industry.
Salient Features
Salient Features
- Institutionalized linkage between University and Industry
- Applicable to all degree programs
- Integral part of the curriculum
- Student involvement in real-life projects
- Continuous Internal Evaluation system
- Monitoring and evaluation by resident faculty member
Concept
IP, of five and a half months duration, carrying twenty units credit, is operated round the year, from July to December and January to June. This facilitates a continuous stream of well-prepared students to work on developmental projects in industry. Since the students participate in and contribute to live projects, they are supported by a stipend.
Aim
IP is directed towards providing an opportunity to students to experience the world of work, by participating in live projects in industry, even before they graduate. Apart from the academic benefits, this also serves to hone their problem solving skills, and build team spirit, initiative, and leadership skills, which makes the eventual transition to the professional world smoother and better.
Methodology
After a brief orientation, students are involved directly in addressing the predefined problems (generally of multidisciplinary nature) of the host organization. The students are encouraged to work independently, under the technical guidance of a professional expert and the general guidance of the faculty. They are periodically required to defend the technical aspects of their work through written and oral presentations. Emphasis is laid on the importance of teamwork, development of leadership qualities, and the need for effective time management.
IP, of five and a half months duration, carrying twenty units credit, is operated round the year, from July to December and January to June. This facilitates a continuous stream of well-prepared students to work on developmental projects in industry. Since the students participate in and contribute to live projects, they are supported by a stipend.
Aim
IP is directed towards providing an opportunity to students to experience the world of work, by participating in live projects in industry, even before they graduate. Apart from the academic benefits, this also serves to hone their problem solving skills, and build team spirit, initiative, and leadership skills, which makes the eventual transition to the professional world smoother and better.
Methodology
After a brief orientation, students are involved directly in addressing the predefined problems (generally of multidisciplinary nature) of the host organization. The students are encouraged to work independently, under the technical guidance of a professional expert and the general guidance of the faculty. They are periodically required to defend the technical aspects of their work through written and oral presentations. Emphasis is laid on the importance of teamwork, development of leadership qualities, and the need for effective time management.
Some IP Projects undertaken by B.Tech Students
Title of the project:: Ericsson Interim Billing System
Name of Student:: Abhimanyu Katoch
IP Organization:: Ericsson India Private Limited
Faculty Mentor:: Amit Kumar
Industry Mentor:: Brajendra Kumar Mishra
Project Summary:: The project had three objectives. The first objective was to design and develop the pdf of the bill, i.e., how the bill of a postpaid user will look like. After getting the design approved by the board the coding of the pdf was done. Enhancements were added to the new design, better look and feel, code refactoring. The second objective was to design the GUI for the service provider operator where they have all the records for all the functions of the postpaid connection like connection, disconnection, new SIM application, old SIM reactivation, plan change, CUG modification, etc. The third objective was to work on Android App development for a client of Ericsson which was also done successfully.
______________________________________________________________________________
Title of Project:: COMPARE MUNAFA ANDROID APPLICATION
Name of Student:: Aayush Thakur
IP Organization:: COMPARE MUNAFA ONLINE PVT. LTD.
Faculty Mentor:: Anirban Bhar
Industry Mentor:: Harsh Maur
Project Summary:: This Android App Development project was completed during the 6 months IP period at Compare Munafa Online Pvt. Ltd. The name of the application is Compare Munafa, which is available on Google Play Store. Methods to complete the project include research on various Android topics online, understanding the Android SDK and Java concepts, making sample applications to test the concepts, and finally implementing them in the main project.
Title of the project:: Ericsson Interim Billing System
Name of Student:: Abhimanyu Katoch
IP Organization:: Ericsson India Private Limited
Faculty Mentor:: Amit Kumar
Industry Mentor:: Brajendra Kumar Mishra
Project Summary:: The project had three objectives. The first objective was to design and develop the pdf of the bill, i.e., how the bill of a postpaid user will look like. After getting the design approved by the board the coding of the pdf was done. Enhancements were added to the new design, better look and feel, code refactoring. The second objective was to design the GUI for the service provider operator where they have all the records for all the functions of the postpaid connection like connection, disconnection, new SIM application, old SIM reactivation, plan change, CUG modification, etc. The third objective was to work on Android App development for a client of Ericsson which was also done successfully.
______________________________________________________________________________
Title of Project:: COMPARE MUNAFA ANDROID APPLICATION
Name of Student:: Aayush Thakur
IP Organization:: COMPARE MUNAFA ONLINE PVT. LTD.
Faculty Mentor:: Anirban Bhar
Industry Mentor:: Harsh Maur
Project Summary:: This Android App Development project was completed during the 6 months IP period at Compare Munafa Online Pvt. Ltd. The name of the application is Compare Munafa, which is available on Google Play Store. Methods to complete the project include research on various Android topics online, understanding the Android SDK and Java concepts, making sample applications to test the concepts, and finally implementing them in the main project.
The first objective was to design and develop the Android app Compare Munafa. After the successful release of the first version , a bug fix version was released. Subsequently, many versions were released with certain enhancements and features. Enhancements were added to the new design, better look and feel, performance boost, code refactoring. Features were implemented such as Firebase cloud Messaging, analytics, crash reporting, animations and large device support in the latest release.
Title of Project:: Information Security Centre for PwC client
Name of Student:: Pranav Narain
IP Organization:: PwC
Faculty Mentor:: Aritra Saha
Industry Mentor:: Manu Dwivedi
Project Summary: The project involves setting up of a Centre that will deal with the management of cyber security threats to the client’s organization. This involves designing processes and workflows from scratch for different cyber division sectors working as a unit within the whole setup. The processes and methodologies are being developed entirely by the PwC’s Cyber Security team, while working hand in hand with the client.
__________________________________________________________________________________________
Name of Student:: Pranav Narain
IP Organization:: PwC
Faculty Mentor:: Aritra Saha
Industry Mentor:: Manu Dwivedi
Project Summary: The project involves setting up of a Centre that will deal with the management of cyber security threats to the client’s organization. This involves designing processes and workflows from scratch for different cyber division sectors working as a unit within the whole setup. The processes and methodologies are being developed entirely by the PwC’s Cyber Security team, while working hand in hand with the client.
__________________________________________________________________________________________
Title of Project:: Security Key Lifecycle Manager (SKLM) and Key Management Interoperability Protocol (KMIP)
Name of Student:: Saarthak Vadhera
IP Organization:: IBM India Pvt. Ltd. (India Software Labs) Pune, India
Faculty Mentor:: Mr. Trupil Limbasiya
Industry Mentor:: Mr. Prashant Mestri, Senior Software Engineer, IBM India Software Labs ‐ Security Systems, Pune, India.
Project Summary:: Encryption and key management is an integral part of managing the growth of sensitive data across the enterprise. IBM Security Key Lifecycle Manager provides exceptional client value because it helps reduce encryption management costs related to setup, use and expiration of encryption keys. It enables organizations to address compliance with disclosure laws and regulations, and it helps ensure against loss of information due to key mismanagement. Security Key Lifecycle Manager transparently detects encryption‐capable media to assign necessary authorization and encryption keys.
Every storage device these days requires ensuring data safety so to secure the data they need to encrypt it and in order to do so they need a key be it a symmetric or asymmetric key. SKLM does is that it follows the Key management interoperability protocol so that it supports all the devices and provides the storage device with a key. The device then uses that key to encrypt the data and maintain security. SKLM has few other features also that include certificate creation and authentication. _________________________________________________________________________________________
Title of Project:: Analysis and Understanding of Asynchronous Parallel Gradient Methods along with its Applications
Name of Student:: Akshita Bhandari
IP Organization:: IISc Bangalore
Faculty Mentor:: Prosenjit Gupta
Industry Mentor:: Chandramani Singh
Project Summary:: The work involved analysing and evaluating random online coordinate descent (ROCD) algorithms. Coordinate descent methods exhibit better complexity in scenario with huge number of features. They also demonstrate same order of regret as the full gradient methods. In this work, ROCD algorithms were used for popularity prediction and caching in information centric networking. The theoretical predictions were confirmed using extensive experiments with both synthetic and real data sets.
_________________________________________________________________________________________
Name of Student:: Saarthak Vadhera
IP Organization:: IBM India Pvt. Ltd. (India Software Labs) Pune, India
Faculty Mentor:: Mr. Trupil Limbasiya
Industry Mentor:: Mr. Prashant Mestri, Senior Software Engineer, IBM India Software Labs ‐ Security Systems, Pune, India.
Project Summary:: Encryption and key management is an integral part of managing the growth of sensitive data across the enterprise. IBM Security Key Lifecycle Manager provides exceptional client value because it helps reduce encryption management costs related to setup, use and expiration of encryption keys. It enables organizations to address compliance with disclosure laws and regulations, and it helps ensure against loss of information due to key mismanagement. Security Key Lifecycle Manager transparently detects encryption‐capable media to assign necessary authorization and encryption keys.
Every storage device these days requires ensuring data safety so to secure the data they need to encrypt it and in order to do so they need a key be it a symmetric or asymmetric key. SKLM does is that it follows the Key management interoperability protocol so that it supports all the devices and provides the storage device with a key. The device then uses that key to encrypt the data and maintain security. SKLM has few other features also that include certificate creation and authentication. _________________________________________________________________________________________
Title of Project:: Analysis and Understanding of Asynchronous Parallel Gradient Methods along with its Applications
Name of Student:: Akshita Bhandari
IP Organization:: IISc Bangalore
Faculty Mentor:: Prosenjit Gupta
Industry Mentor:: Chandramani Singh
Project Summary:: The work involved analysing and evaluating random online coordinate descent (ROCD) algorithms. Coordinate descent methods exhibit better complexity in scenario with huge number of features. They also demonstrate same order of regret as the full gradient methods. In this work, ROCD algorithms were used for popularity prediction and caching in information centric networking. The theoretical predictions were confirmed using extensive experiments with both synthetic and real data sets.
_________________________________________________________________________________________
Title of Project:: A Software Defined Radio based Framework for the Co-existence of
multiple Heterogeneous Devices in Industrial Internet of Things
Name of Student:: Shivam Vinayak Vatsa
IP Organization:: TCS Innovation Labs
Faculty Mentor:: Prosenjit Gupta
Industry Mentor:: Rajeev Shorey
Project Summary:: The Internet of Things (IoT) paradigm has immersed as a key component in diverse areas ranging from Smart Homes, Transportation and Health Care to Supply Chain and Smart Manufacturing. This project proposes a framework based on Software Defined Radio (SDR) and leverages TV white spaces in order to meet the spectrum scarcity and provide non-interfering co-existence of various collocated radio enabled IoT devices. Spectrum sensing is a pre-requisite for dynamic spectrum access. Spectrum sensing is a repetitive process and would consume extra energy from the IoT nodes. It is to be noted that IoT devices are characterized by low power; hence it would inefficient to deploy spectrum sensing at device level. The project has proposed a centralized collaborative spectrum sensing architecture which is efficient in term of power consumption.
multiple Heterogeneous Devices in Industrial Internet of Things
Name of Student:: Shivam Vinayak Vatsa
IP Organization:: TCS Innovation Labs
Faculty Mentor:: Prosenjit Gupta
Industry Mentor:: Rajeev Shorey
Project Summary:: The Internet of Things (IoT) paradigm has immersed as a key component in diverse areas ranging from Smart Homes, Transportation and Health Care to Supply Chain and Smart Manufacturing. This project proposes a framework based on Software Defined Radio (SDR) and leverages TV white spaces in order to meet the spectrum scarcity and provide non-interfering co-existence of various collocated radio enabled IoT devices. Spectrum sensing is a pre-requisite for dynamic spectrum access. Spectrum sensing is a repetitive process and would consume extra energy from the IoT nodes. It is to be noted that IoT devices are characterized by low power; hence it would inefficient to deploy spectrum sensing at device level. The project has proposed a centralized collaborative spectrum sensing architecture which is efficient in term of power consumption.
Title of Project::
1. Insurance based virtual agent (ABC Insurance, Singapore)
2. Marketing & due diligence (Bacardi, USA)
3. Optimal price point determination (Oxxo, Mexico)
Name of Student:: Faiz M. Qureshi
IP Organization:: IBM India Pvt. Ltd.
Faculty Mentor:: Suman Sanyal
Industry Mentor:: Siddhartha S Roy
Project Summary:
1. To develop and deploy a virtual chat agent web app. This app will aid insurance companies
target new customers as well as improve service to existing customers. We aim to make
conversation natural and human.
2. To provide a method for Bacardi US to use social media marketing responsibly. Aim here is to
build profiles of two groups - under and over-age users, from their twitter data. By
differentiating between these groups, we can proceed to exclude underage users from our
marketing campaign.
3. Oxxo, a Mexican chain of convenience stores wishes to determine the optimal price to sell its
products, so as to maximize revenue. Our objective here is to provide interactive, elegant and
effortless data visualization, which could be used by the project leads to explain the modeling
results to the client.
_________________________________________________________________________________________
Title of Project:: SCREENING OF MATRICES FOR LIPASE IMMOBLIZATION
Name of Student:: K.REVATHI
IP Organization:: Bhabha Atomic Research Centre, Mumbai
Faculty Mentor:: Sunil Khanna
Industry Mentor:: Dr. JS Melo
Project Objectives::
1. Insurance based virtual agent (ABC Insurance, Singapore)
2. Marketing & due diligence (Bacardi, USA)
3. Optimal price point determination (Oxxo, Mexico)
Name of Student:: Faiz M. Qureshi
IP Organization:: IBM India Pvt. Ltd.
Faculty Mentor:: Suman Sanyal
Industry Mentor:: Siddhartha S Roy
Project Summary:
1. To develop and deploy a virtual chat agent web app. This app will aid insurance companies
target new customers as well as improve service to existing customers. We aim to make
conversation natural and human.
2. To provide a method for Bacardi US to use social media marketing responsibly. Aim here is to
build profiles of two groups - under and over-age users, from their twitter data. By
differentiating between these groups, we can proceed to exclude underage users from our
marketing campaign.
3. Oxxo, a Mexican chain of convenience stores wishes to determine the optimal price to sell its
products, so as to maximize revenue. Our objective here is to provide interactive, elegant and
effortless data visualization, which could be used by the project leads to explain the modeling
results to the client.
_________________________________________________________________________________________
Title of Project:: SCREENING OF MATRICES FOR LIPASE IMMOBLIZATION
Name of Student:: K.REVATHI
IP Organization:: Bhabha Atomic Research Centre, Mumbai
Faculty Mentor:: Sunil Khanna
Industry Mentor:: Dr. JS Melo
Project Objectives::
- Optimization of parameters for binding of Candida rugosa lipase (CRL) enzyme to different cloth matrix.
- Physico-chemical and biochemical characterization of immobilized matrix.
Project Summary::
After screening various cloth matrix, we found that even though some matrix like plain cheese cloth had good immobilization efficiency, the reusability was very poor. Cross linking also did not help in capping the enzyme to prevent desorption. Only, the graphite coated glass cloth matrix was retaining its initial activity even after 10 reuses. Therefore, to improve the immobilization efficiency, the matrix was pre-treated with tert-butanol to decrease its hydrophobicity which was hindering the binding of CRL.There was a threefold increase in enzyme bound to the graphite matrix after pre-treatment. The immobilized matrix retained its initial activity even after 9 reuses when washed with tert-butanol (5%v/v) after each hydrolysis reaction. The optimum pH and temperature of the matrix was determined to 7 and 45°C. The 𝐾𝑚 and Vmax of the immobilized CRL and free CRL was found for four different oils. The 𝐾𝑚 for the olive oil was same for immobilized and free CRL indicating similar affinity for the substrate whereas the 𝐾𝑚 for the sunflower oil was less for the immobilized CRL as compared to the free CRL indicating immobilization increased the affinity of the enzyme for the substrate. The physic-chemical characterization gave us an insight into the properties of the matrices like hydrophobicity.
Overall, the graphite coated glass cloth matrix could find its application in industrial processes like trans esterification etc because of its mechanical stability, good immobilization efficiency and reusability without loss of enzyme.
_________________________________________________________________________________________
Title of Project:: CLONING, EXPRESSION AND CHARACTERIZATION OF RECOMBINANT LIPASE IN Pichia pastoris
Name of Student:: Kandhadi Sandhya Reddy
IP Organization:: Nagarjuna Innovation centre (NIC)
Faculty Mentor:: Sunil Khanna
Industry Mentor:: Dr.G. Satheesh kumar
Project Objectives::
Development and expression of mutant Lipase (mkL1.1) having sn-1,3specificity in Pichia pastoris
Project Summary::
Lipases (triacylglycerol acylhydrolases, EC 3.1.1.3) catalyze the hydrolysis of triacylglycerols and the synthesis of esters formed from glycerol and long-chain fatty acids. Lipases occur widely in nature, but only microbial lipases are commercially significant. Lipase having sn1,3 specific activity have been expressed in Pichia pastoris and the upstream process have been developed by the IP Organisation (NIC, NFCL), but left a scope for further improvement of lipase activity by improving post translation modifications of the protein i.e protein maturation. Also Lipase(L4) having sn2 specific activity have been purified and characterized. This project details about expression of Recombinant Lipase , their purification and characterization.
_________________________________________________________________________________________
Title of Project:: Identification of novel α-secretase-regulating synthetic molecules
Name of Student:: Prachi Singh
IP Organization:: Institute of Molecular Biosciences, Mahidol University, Thailand
Faculty Mentor:: Sunil Khanna
Industry Mentor:: Dr. Bruno Vincent
Project Objectives::
Development and expression of mutant Lipase (mkL1.1) having sn-1,3specificity in Pichia pastoris
Project Summary::
Alzheimer’s disease is posing a major health threat to the population, specifically the elderly. Indeed, this neurodegenerative disorder concerns 1 out of 3 individuals over 85 of age. Moreover, in United States, the annual cost of caring for people with AD is about $183 billion. Hence, we are looking forward to research to offer hope of prevention and an eventual cure for AD. The generation of amyloid β-peptide (Aβ) by enzymatic cleavages of the β-amyloid precursor protein (βAPP) is at the center of Alzheimer’s disease (AD) research. The identification of new compounds as anti-Aβ medication is an attractive approach for AD therapy. In this study, we searched for agents able to efficiently shift βAPP processing towards the non-amyloidogenic α-secretase pathway. Here we have identified three novel compounds able to activate the α- secretase-mediated non amyloidogenic processing of βAPP in human HEK293 non-neuronal cells as well as in mouse N2a and human SH-SY5Y neuroblastoma cell lines. These synthetic molecules can further be modified and studied as potential therapeutic agents.
After screening various cloth matrix, we found that even though some matrix like plain cheese cloth had good immobilization efficiency, the reusability was very poor. Cross linking also did not help in capping the enzyme to prevent desorption. Only, the graphite coated glass cloth matrix was retaining its initial activity even after 10 reuses. Therefore, to improve the immobilization efficiency, the matrix was pre-treated with tert-butanol to decrease its hydrophobicity which was hindering the binding of CRL.There was a threefold increase in enzyme bound to the graphite matrix after pre-treatment. The immobilized matrix retained its initial activity even after 9 reuses when washed with tert-butanol (5%v/v) after each hydrolysis reaction. The optimum pH and temperature of the matrix was determined to 7 and 45°C. The 𝐾𝑚 and Vmax of the immobilized CRL and free CRL was found for four different oils. The 𝐾𝑚 for the olive oil was same for immobilized and free CRL indicating similar affinity for the substrate whereas the 𝐾𝑚 for the sunflower oil was less for the immobilized CRL as compared to the free CRL indicating immobilization increased the affinity of the enzyme for the substrate. The physic-chemical characterization gave us an insight into the properties of the matrices like hydrophobicity.
Overall, the graphite coated glass cloth matrix could find its application in industrial processes like trans esterification etc because of its mechanical stability, good immobilization efficiency and reusability without loss of enzyme.
_________________________________________________________________________________________
Title of Project:: CLONING, EXPRESSION AND CHARACTERIZATION OF RECOMBINANT LIPASE IN Pichia pastoris
Name of Student:: Kandhadi Sandhya Reddy
IP Organization:: Nagarjuna Innovation centre (NIC)
Faculty Mentor:: Sunil Khanna
Industry Mentor:: Dr.G. Satheesh kumar
Project Objectives::
Development and expression of mutant Lipase (mkL1.1) having sn-1,3specificity in Pichia pastoris
Project Summary::
Lipases (triacylglycerol acylhydrolases, EC 3.1.1.3) catalyze the hydrolysis of triacylglycerols and the synthesis of esters formed from glycerol and long-chain fatty acids. Lipases occur widely in nature, but only microbial lipases are commercially significant. Lipase having sn1,3 specific activity have been expressed in Pichia pastoris and the upstream process have been developed by the IP Organisation (NIC, NFCL), but left a scope for further improvement of lipase activity by improving post translation modifications of the protein i.e protein maturation. Also Lipase(L4) having sn2 specific activity have been purified and characterized. This project details about expression of Recombinant Lipase , their purification and characterization.
_________________________________________________________________________________________
Title of Project:: Identification of novel α-secretase-regulating synthetic molecules
Name of Student:: Prachi Singh
IP Organization:: Institute of Molecular Biosciences, Mahidol University, Thailand
Faculty Mentor:: Sunil Khanna
Industry Mentor:: Dr. Bruno Vincent
Project Objectives::
Development and expression of mutant Lipase (mkL1.1) having sn-1,3specificity in Pichia pastoris
Project Summary::
Alzheimer’s disease is posing a major health threat to the population, specifically the elderly. Indeed, this neurodegenerative disorder concerns 1 out of 3 individuals over 85 of age. Moreover, in United States, the annual cost of caring for people with AD is about $183 billion. Hence, we are looking forward to research to offer hope of prevention and an eventual cure for AD. The generation of amyloid β-peptide (Aβ) by enzymatic cleavages of the β-amyloid precursor protein (βAPP) is at the center of Alzheimer’s disease (AD) research. The identification of new compounds as anti-Aβ medication is an attractive approach for AD therapy. In this study, we searched for agents able to efficiently shift βAPP processing towards the non-amyloidogenic α-secretase pathway. Here we have identified three novel compounds able to activate the α- secretase-mediated non amyloidogenic processing of βAPP in human HEK293 non-neuronal cells as well as in mouse N2a and human SH-SY5Y neuroblastoma cell lines. These synthetic molecules can further be modified and studied as potential therapeutic agents.
Post a Comment